发给老马备查:
1 V6 l7 I w1 ?" A \5 q滴水察海(69304838) 15:23:232 T, X3 v; l$ s9 K8 h
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱1 j8 A c' a0 |5 F
吉非替尼和S-1连用的依据9 j( {0 ~: @, `* b3 ]6 G: o0 ?$ t
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
3 s8 ]) ?) B& Y" v/ l是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
: Q4 T( l' c. N# Z, ]这样是不是推理出,耐药后,可以用S-1和培美了?* u3 Q8 U/ C, W5 k- x; p
结论:5 N5 I2 x o9 N9 A* h! V. e
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |