发给老马备查:; {: ?2 m! L7 f2 g
滴水察海(69304838) 15:23:23
- U$ E3 S K4 b. h' |4 t老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
; r, a9 v8 S+ l) ?$ N& L0 X吉非替尼和S-1连用的依据
4 _* l3 l0 @$ g$ a) _# K( O8 oGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
; C3 H/ o7 ~, O* w$ p/ t& D5 V7 E是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达: W. ^1 M; U" G2 ^
这样是不是推理出,耐药后,可以用S-1和培美了?
( T/ i e0 M# u" `结论:
! V, @" T* J Z' O1 s1 n" ?8 |如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |