发给老马备查:; Q5 g0 m9 @; {% u
滴水察海(69304838) 15:23:23
7 \7 \$ I" W" B% I( E1 w% [老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱8 B0 t1 W" l+ t3 d/ K1 p8 S+ p" z
吉非替尼和S-1连用的依据5 R, X" U' O, _+ M7 p1 j
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
0 a9 c0 p/ u1 A. r3 z是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达; G. _6 u# R/ {- O
这样是不是推理出,耐药后,可以用S-1和培美了?- O- ^9 V5 {/ W4 G
结论:
4 Z" x" q+ I8 L, P" T* s2 P如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |