发给老马备查:
7 D! I5 n. @2 k7 I# k滴水察海(69304838) 15:23:23. f& ?% [ c5 g; v: z
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
! p+ V w2 k2 o吉非替尼和S-1连用的依据
& o( W7 S8 @" L# J7 \, L8 xGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
0 o5 _/ n! q' u# M) N* o, N是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
8 w6 k, a. p: {/ k这样是不是推理出,耐药后,可以用S-1和培美了?
/ W5 g ~+ ` q) H结论:
3 d- s! @3 F. q& j! \3 E: P如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |