发给老马备查:7 {/ W' X, ^' v; [! n6 {
滴水察海(69304838) 15:23:232 `- H7 e- t9 \* ]* S# z- w, k
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
% P0 G9 z T" j- z9 s. S" C吉非替尼和S-1连用的依据
3 ` T* o8 m! [8 Y, |Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
2 }' {9 v9 t6 {. r( g9 k( z是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达/ F8 L7 B+ b5 E: V, C/ |1 ?
这样是不是推理出,耐药后,可以用S-1和培美了?# R4 W# Z' z, J! F& u; k
结论:
/ c3 c- I& y* M0 B6 @3 J如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |