本帖最后由 老马 于 2013-3-13 13:43 编辑 / h( P" F4 j: p6 n* Y
% V; z; [% {& T7 y+ c: A/ {: U健择(吉西他滨)+顺铂+阿瓦斯汀. S* \ N0 a7 w- s: F8 m4 J1 g$ i
Gemzar +Cisplatin + Avastin
8 v% a$ v8 m3 I* bhttp://annonc.oxfordjournals.org/content/21/9/1804.full5 {0 O$ o: q- i- m
Overall survival with cisplatin–gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
0 q0 D4 @) L% c I( kPatients and methods: Patients (n = 1043) received cisplatin 80 mg/m2 and gemcitabine 1250 mg/m2 for up to six cycles plus bevacizumab 7.5 mg/kg (n = 345), bevacizumab 15 mg/kg (n = 351) or placebo (n = 347) every 3 weeks until progression. Primary end point was progression-free survival (PFS); OS was a secondary end point. " ~; i' `( L2 w7 B
Results: Significant PFS prolongation with bevacizumab compared with placebo was maintained with longer follow-up {hazard ratio (HR) [95% confidence interval (CI)] 0.75 (0.64–0.87), P = 0.0003 and 0.85 (0.73–1.00), P = 0.0456} for the 7.5 and 15 mg/kg groups, respectively. Median OS was >13 months in all treatment groups; nevertheless, OS was not significantly increased with bevacizumab [HR (95% CI) 0.93 (0.78–1.11), P = 0.420 and 1.03 (0.86–1.23), P = 0.761] for the 7.5 and 15 mg/kg groups, respectively, versus placebo. Most patients (62%) received multiple lines of poststudy treatment. Updated safety results are consistent with those previously reported.
2 s% Y9 J. j8 `5 q
Cisplatin Gemzar Avastin.PDF
(329.84 KB, 下载次数: 923)
/ V, p- }! K7 Y3 X8 ^华为网盘附件:# Z& }( U' ?. }' { U0 c
【华为网盘】ava.JPG! t, i' E/ }, Q! G& r
|