平安! 发表于 2011-11-9 19:57 ( o5 p7 P1 w" Q* L8 G: }
Pazopanib (100 mg/kg/day free base equivalent)
1 S8 m' ?4 Y# a7 l. t 这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。6 ~* x8 K' P: H0 a3 T
搜索了一下,原料一大堆。
: f' i% E0 Q. r ^2 L! l; p( ~0 u0 Y, y
对不起!100mg/kg是用于移植瘤的,我弄错了。4 e7 I' i& Z, Q: v9 P- Z" m; [
" [! w9 ] U; k, X1 i
以下是正版说明书的推荐用量。! D% [5 ?# }/ T5 }# X
4 S3 r6 ~; L8 v9 Q1 L( w/ q, V l& t
--------------------- DOSAGE AND ADMINISTRATION ----------------
8 f% M$ t& e( C: s, d* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1) . \3 t9 O2 a( S* r2 s) E
* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2) 6 I1 V& \* L* c, K
---------------------DOSAGE FORMS AND STRENGTHS --------------9 o& {) f' w* L" m* P. y
200 mg tablets. (3) . n; I- A/ R4 o0 |
-------------------------------CONTRAINDICATIONS------------------------ |