平安! 发表于 2011-11-9 19:57 4 G3 d7 j/ q9 Z) Q% r3 c! ~9 t( Y0 O
Pazopanib (100 mg/kg/day free base equivalent)
& T; [1 P% }8 n6 J( |1 |7 d7 [ 这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。
* b, g3 W! `' B' Z" k f搜索了一下,原料一大堆。, Q. w* `2 y( M/ s
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对不起!100mg/kg是用于移植瘤的,我弄错了。
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以下是正版说明书的推荐用量。# j# S! p3 g5 {" h' e/ f
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--------------------- DOSAGE AND ADMINISTRATION ----------------+ ^2 O! P0 T2 A* E% y
* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1) ! O; q- q2 H; d5 Y6 X4 Q
* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2) 3 N: q$ }' l; H+ h
---------------------DOSAGE FORMS AND STRENGTHS --------------
# E6 w- X* [0 p7 S200 mg tablets. (3)
" F! ?, M; P) X2 z& q9 I/ C- S9 m-------------------------------CONTRAINDICATIONS------------------------ |