平安! 发表于 2011-11-9 19:57
3 U: Y: J, ^# _Pazopanib (100 mg/kg/day free base equivalent)
7 L' h+ L" b. y2 ^ 这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。. r: _) B o- G! b8 o6 E
搜索了一下,原料一大堆。
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/ X5 q+ u; l) Q8 S, F对不起!100mg/kg是用于移植瘤的,我弄错了。
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以下是正版说明书的推荐用量。( h. }0 O2 u; s
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--------------------- DOSAGE AND ADMINISTRATION ----------------5 m+ ]: B0 ]+ u7 i8 @
* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1) ; Z" Z$ ?3 ]) n5 `
* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2) ! J' @: {3 Q! N9 J, _/ d4 p
---------------------DOSAGE FORMS AND STRENGTHS --------------
* |! I, Q. A) r200 mg tablets. (3) ! Z$ h }6 s# z' g
-------------------------------CONTRAINDICATIONS------------------------ |