看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies.
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Combination Feasibility according to preliminary data , W4 \, ^' W0 q. J& q8 C
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$ Y! ^5 A1 N3 GBevacizumab + sorafenib Yes, reduced dose # d9 o/ L$ ]& L# B6 o% F
Bevacizumab + sunitinib† No
2 q! o i( p$ l) a. M# G e. S4 zBevacizumab + temsirolimus Yes
P) l3 Y4 a, U, V# qBevacizumab + everolimus Yes
K" P' {- x$ @2 U2 H+ T9 TSorafenib + sunitinib ? % ?7 @# a% M0 b- S$ G( w
Sorafenib + temsirolimus Yes, reduced dose & O6 ~7 c m% o, o% ?; b
Sorafenib + everolimus Yes, reduced dose 9 R& c' _" k+ Y$ y
Sunitinib + temsirolimus† No ; t! X# I6 j0 n7 ~# M
Sunitinib + everolimus ? . V6 Y3 f! \9 \5 ?7 P' y& _
Temsirolimus + everolimus ?
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4 ?4 |# l& I1 i+ C2 ~†Led to US FDA warning.
5 R) ^3 {5 T2 h2 T?: As yet unattempted combination.3 l; |6 l( f; K2 e0 Z g; y7 d
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