看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。3 r2 u8 C6 d! I# s/ Y0 n- }5 S8 A
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Currently available feasibility data for possible combination strategies. 1 ]3 o2 d; c: Q% b- C6 k
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Combination Feasibility according to preliminary data $ r6 |5 t3 n( S* Y3 s: x& p- V
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Bevacizumab + sorafenib Yes, reduced dose % T$ y2 g/ x- h
Bevacizumab + sunitinib† No
/ s0 H. F% O: \; U+ j, RBevacizumab + temsirolimus Yes 2 _$ w' w1 k2 R, X, R! Z% J
Bevacizumab + everolimus Yes 8 a/ C' v" l4 o& m7 A: ?1 R; L
Sorafenib + sunitinib ?
- a$ p* c& O$ F# z TSorafenib + temsirolimus Yes, reduced dose
5 R3 j2 r) P% t' K& SSorafenib + everolimus Yes, reduced dose $ y+ F& z" o4 e* @
Sunitinib + temsirolimus† No $ h. M3 {9 g- O% u) d# g+ ^
Sunitinib + everolimus ? 9 t* U' x% k) n7 @7 z' B' w
Temsirolimus + everolimus ? % ~2 x+ X) u8 I8 j( D7 k
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# b/ L4 P0 c5 c1 e7 r4 S- \5 N- O†Led to US FDA warning.' s& ?( U8 y! X
?: As yet unattempted combination.& o+ H/ ?! N4 I+ e$ Q {; ?/ a- P
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