看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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! R3 \: K2 b+ A6 I2 rCurrently available feasibility data for possible combination strategies.
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Combination Feasibility according to preliminary data 8 M: e* V( Y8 k& n7 F8 l! y4 H
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/ k& ?$ e$ N- X! w1 g0 F1 M8 E# eBevacizumab + sorafenib Yes, reduced dose
. o% l! Q% J5 gBevacizumab + sunitinib† No 4 Q2 w, j# {1 R' }+ a
Bevacizumab + temsirolimus Yes
$ c" z. o, G1 [" F1 ?& NBevacizumab + everolimus Yes : z# F; a' T% u& E/ t0 C% t2 s) d1 t
Sorafenib + sunitinib ? " m- L4 m! ] Y6 C+ \; C% n
Sorafenib + temsirolimus Yes, reduced dose / w( D. _+ b7 L" @
Sorafenib + everolimus Yes, reduced dose " i3 J9 V( d$ V) B' X" @0 g
Sunitinib + temsirolimus† No $ S! r* M6 i9 [: o9 \, Y
Sunitinib + everolimus ?
+ m% q: g1 V3 T7 rTemsirolimus + everolimus ? ; b# d0 D2 E- o& R2 }5 L
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†Led to US FDA warning.
+ |, a# ]8 O |0 Q4 V?: As yet unattempted combination.
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